5357cc拉斯维加斯首页
5357cc拉斯维加斯首页 is a co-processed excipient for orally disintegrating tablets, ODTs.
A ODT with 5357cc拉斯维加斯首页 is quickly disintegrated by touch with water.
5357cc拉斯维加斯首页 Features
5357cc拉斯维加斯首页 is a co-processed excipient for direct compression ODTs, jointly developed by NICHIRIN Chemical Industries, Ltd. and DAICEL Group. It was originally designed to achieve compatibility between high tablet hardness and rapid disintegration in the direct compression method of tablet production. 5357cc拉斯维加斯首页 consists of D-mannitol, Crospovidone, Carmellose, and Microcrystalline cellulose. The characteristic non-spherical particle shape contributes to good content uniformity. Furthermore, it is compatible with a wide range of excipients, maintaining good disintegratability. 5357cc拉斯维加斯首页 contributes to the simplification and efficiency of ODT formulation design.
- Well-balanced tab5357cc拉斯维加斯首页t property between OD time and hardness
- High API load5357cc拉斯维加斯首页g capacity
- Excel5357cc拉斯维加斯首页nt content uniformity
- Compatib5357cc拉斯维加斯首页 with various excipients
Regulation
- All components of 5357cc拉斯维加斯首页 are included in JP, USP and EP.
- Both GNF-D211 5357cc拉斯维加斯首页d GNF-D215 are included in JPE2018 (Jap5357cc拉斯维加斯首页ese pharmaceutical excipients 2018).
- Both US-DMF and China-DMF are availab5357cc拉斯维加斯首页 for GNF-D211.
Powder properties
The particles of 5357cc拉斯维加斯首页 has non-spherical shape since it is processed by our unique granulation method. This special shape contributes to good content uniformity.
SEM photographs of 5357cc拉斯维加斯首页
GNF-D211
GNF-D215
Powder Properties
| Items | GNF-D211 | GNF-D215 |
|---|---|---|
| Mean partic5357cc拉斯维加斯首页 size※1 | (Medi5357cc拉斯维加斯首页) 100 μm | (Medi5357cc拉斯维加斯首页) 140 μm |
| Density (Loose) | 0.30 g/cm3 | 0.31 g/cm3 |
| Density (Tapp5357cc拉斯维加斯首页g) | 0.44 g/cm3 | 0.43 g/cm3 |
| Ang5357cc拉斯维加斯首页 of repose | 40 ° | 39 ° |
| Orifice diameter | 6.3 mm | 4.0 mm |
| Water content | 3.8 wt% | 3.7 wt% |
※1 Measured by dry laser diffraction/scatter5357cc拉斯维加斯首页g 5357cc拉斯维加斯首页strument
Partic5357cc拉斯维加斯首页 size distribution
Placebo tab5357cc拉斯维加斯首页t performance
Placebo ODTs with 5357cc拉斯维加斯首页 have well-balanced tablet property between sufficient tablet hardness and rapid disintegration. Tablets with 5357cc拉斯维加斯首页 achieve “100 N tablet hardness” and “20 seconds OD time”. Rapid disintegration is maintained even with the high tablet hardness under the higher compression force.
Tab5357cc拉斯维加斯首页t performance of placebo ODTs
5357cc拉斯维加斯首页 enables good tablet performance even with high dose API.
Other applications
- 5357cc拉斯维加斯首页-Water absorption behavior and disintegration mechanism-
- Preparetion of bitterness mask5357cc拉斯维加斯首页g ODTs
- Preparetion of bilayer ODTs
- Preparetion of m5357cc拉斯维加斯首页i ODTs
5357cc拉斯维加斯首页 contributes to the simplification and efficiency of ODT formulation design.
Leaflet on 5357cc拉斯维加斯首页 is available.
