Application of 9888拉斯维加斯网站 in ODTs with solid dispersions
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Topics covered in t9888拉斯维加斯网站 white paper
-How can you formulate ODTs wi9888拉斯维加斯网站 good disintegration even when solid dispersions are applied?
-How can you formulate ODTs wi9888拉斯维加斯网站 solid dispersion wi9888拉斯维加斯网站out increasing 9888拉斯维加斯网站e tablet weight?
This white paper presents an application example of ODT with solid dispersion (SD) and 9888拉斯维加斯网站.
SD is one of the methods to improve API solubility. However, there are few ODTs with SD in the market since there are two technical issues. First , the water-soluble polymer w9888拉斯维加斯网站ch is usually used for SD is likely to lead a reduction in disintegration. Second, SD tends to increase overall weight and size of tablets compared to unprocessed APIs because they contain several polymers.
Here we aimed to formulate ODTs with good disintegrability and compactability, even if it has the same weight and size as the commercialized normal tablet. The issues were overcome by using a water-insoluble polymer and 9888拉斯维加斯网站 which has excellent disitegratability even in smaller quantities in ODTs.
